activE clinical trials

Recruiting Patients as of February 2017

Completed

publishEd research

Human Studies

Prevalence and Patterns of Marijuana Use in Young Adults With Inflammatory Bowel Disease (2017)

Patterns of cannabis use in patients with Inflammatory Bowel Disease: A population based analysis (2015)

Systematic review of complementary and alternative medicine treatments in inflammatory bowel diseases (2015)

Cannabis for Inflammatory Bowel Disease (2014)

Cannabis use provides symptom relief in patients with inflammatory bowel disease but is associated with worse disease prognosis in patients with Crohn’s disease (2014)

The holistic effects of cannabis in Crohn’s disease (2014)

Marijuana use patterns among patients with inflammatory bowel disease (2013)

Cannabis use amongst patients with inflammatory bowel disease (2011)

Use of complementary and alternative medicine and drug abuse in patients with inflammatory bowel disease (2007)

Rodent Studies

An Orally Active Cannabis Extract with High Content in Cannabidiol attenuates Chemically-induced Intestinal Inflammation and Hypermotility in the Mouse (2016)

Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment (2016)

In vitro and non-invasive in vivo effects of the cannabinoid-1 receptor (CB1R) agonist AM841 on gastrointestinal motor function in the rat (2015)

Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH) (2014)

Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract (2013)

Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (CBG) (2013)

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis (CBC) (2013)

The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis (2013)

Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice (CBC) (2012)

Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice (2012)

The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis (2010)

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis (2009)

Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice (2008)

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis (2009)

The endocannabinoid system in the physiology and pathophysiology of the gastrointestinal tract (2005)

In Vitro 

Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (2011)

Reviews

Role of cannabis in digestive disorders (2017)

Cannabis and Pediatric Inflammatory Bowel Disease: Change Blossoms a Mile High (2017)

Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review (2017)

Therapeutic Use of Cannabis in Inflammatory Bowel Disease (2016)

Complementary Therapies in Inflammatory Bowel Diseases (2016)

Dietary Supplement Therapies for Inflammatory Bowel Disease: Crohn’s Disease and Ulcerative Colitis (2016)

The gastrointestinal tract – a central organ of cannabinoid signaling in health and disease (2016)

Endocannabinoids in the Gut (2016)

Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation (2016)

Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review (2015)

Narrative review of the safety and efficacy of marijuana for the treatment of commonly state-approved medical and psychiatric disorders (2015)

Herbal and plant therapy in patients with inflammatory bowel disease (2015)

Cannabis finds its way into treatment of Crohn’s disease (2014)

Cannabidiol in inflammatory bowel diseases: a brief overview (2013)

Cannabinoids and the gastrointestinal tract (2001)

KEY PRESENTATION:

Unpublished data & trials from Dr. Naftali from Israel, PI of almost all clinical trials on cannabis & CBD for Crohn’s disease